Clinical Trials & Research

Researchers worldwide hypothesized that the development of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could help to reduce transmission and help to lower the mortality rate. The vaccines developed against coronavirus disease 2019 (COVID-19) had to undergo several clinical trials before they could be considered safe for human use. Patients of various age
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Scientists have recently tried to explain the factors that could be responsible for the recent outbreaks of coronavirus disease 2019 (COVID-19) in Israel. Their observations reveal that the prevalence of the more infectious delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and waning vaccine efficacy results in the outbreaks. As preventive interventions, they
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People of advanced age who are overweight or obese with a higher level of adherence to the Mediterranean diet preserve their cognitive performance and even improve their abilities after three years, according to a new study. The Mediterranean diet does not only have beneficial effects for the cardiovascular health of those who follow it, but
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India has suffered from high transmission and death rates during the coronavirus disease 2019 (COVID-19) pandemic. The rise of the delta variant has also been a major concern, as it is known to evade immunity induced from previous strains. Researchers decided to investigate how effective immunity gained from previous severe acute respiratory syndrome coronavirus 2
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Jumpcode Genomics, a genome technology platform company focused on improving the understanding of human biology, announced today a collaboration with the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, to aid investigations into the genomic epidemiology of SARS-CoV-2, the virus that causes COVID-19. Jumpcode Genomics and TGen are validating novel comprehensive solutions
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NHS Test and Trace had a significant impact on driving down levels of COVID-19 transmission between June 2020 to April 2021, new modeling published today shows. From June 2020 to April 2021, testing, contact tracing and self-isolation directly prevented somewhere between 1.2 million and 2 million COVID-19 infections. Since its inception, NHS Test and Trace
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Beckman researchers paired microscopy with artificial intelligence to develop a COVID-19 test that’s fast, accurate, and cost-effective. All we need to do is say “ahh.” Many of us have encountered or experienced a COVID-19 test. Like the pandemic itself, frequent screening has become part of daily life. As SARS-CoV-2 continues to be a formidable foe,
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Sandrine V. Pierre, Ph.D., associate professor of biomedical sciences at the Marshall University Joan C. Edwards School of Medicine and interim director of the Marshall Institute for Interdisciplinary Research (MIIR), has been awarded a Research Project Grant (R01), one of the most competitive grants issued by the National Institutes of Health (NIH). Pierre was awarded
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GAITHERSBURG, Md., Sept. 8, 2021 /PRNewswire/ — Novavax, Inc. (Nasdaq: NVAX), a biotechnology company dedicated to developing and commercializing next-generation vaccines for serious infectious diseases, today announced enrollment of the first participants in a Phase 1/2 study to evaluate the safety and immunogenicity of a combination vaccine using Novavax’ seasonal influenza and COVID-19 vaccines. The
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In a study conducted at the Mayo Clinic, USA, scientists have investigated the long-term efficacy of the mRNA-based coronavirus disease 2019 (COVID-19) vaccine BNT162b2 (Pfizer/BioNTech) against symptomatic disease. The findings reveal that although breakthrough infections occur in fully vaccinated individuals, the vaccine remains effective against symptomatic COVID-19 several months after full vaccination. The study is
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LA ROCHELLE, France. Sept 6, 2021 – Valbiotis, a French research and development company committed to scientific innovation for preventing and combating metabolic diseases, announces that it has completed the recruitment of 120 volunteers for the Phase II HEART clinical study at the beginning of September 2021, in accordance with the schedule announced by the
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Individuals affected by autism spectrum disorder often present communication issues and difficulties in social interactions. Although very frequent, this disorder is challenging to diagnose before the age of five. However, early care can compensate for these difficulties by providing specific behavioral intervention focused on the development of skills affected by autism. This is why an
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SAN FRANCISCO, Sept. 3, 2021.  Quantum Leap Healthcare Collaborative, the sponsor of the I-SPY COVID Trial, today announced that the Famotidine Celecoxib arm has been dropped from the trial due to futility, based on the low likelihood of success. The Famotidine Celecoxib combination was chosen for testing because of their anti-histamine and anti-inflammatory mechanism of
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Don and Karen Cohn have given $2.5 million to create the Don and Karen Cohn Chancellor’s Endowed Chair in Neurosurgery at University of California San Diego School of Medicine. The gift will support excellence in research, education and clinical care in the field of neurological surgery. Alexander Khalessi, MD, neurosurgeon at UC San Diego Health,
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MANHASSET, N.Y., Sept. 2, 2021. As part of a new National Institutes of Health (NIH) coronavirus disease 2019 (COVID-19) vaccine clinical trial, The Feinstein Institutes for Medical Research – the science arm of Northwell Health – delivered its first set of extra shots to eligible New York patients with an autoimmune disease. An estimated 8
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A recent study looks at the implications of pausing vaccinations against coronavirus disease 2019 (COVID-19) due to blood clotting concerns that occurred around mid-March 2021. While the vaccine’s benefits outweigh the risks, the study findings suggest that the pause had no significant impact on the subsequent vaccine uptake in the European countries. Study: The impact
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MADRID, Aug. 31, 2021. Results from a new human clinical study demonstrate a significant capacity for Pharmactive’s potent all-natural affron standardized saffron extract to promote restorative sleep. The ingredient showed its effect in a single, low dose taken just one hour before bedtime, making affron a natural ingredient that is very easy to consume. Moreover,
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Postmortem genetic testing, or genomic autopsy, of young individuals who experienced sudden death revealed many had known genetic variants that are associated with cardiomyopathy, according to a Northwestern Medicine study published in JAMA Cardiology. These findings indicate that genomic autopsy can improve care for families after a sudden death in a young patient, as it
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ABBOTT PARK, Ill., Aug. 27, 2021.  Abbott today announced results of the landmark GUIDE-HF clinical trial, a 1,000 patient randomized study designed to assess the benefits of the CardioMEMS HF System in people living with NYHA Class II, III and IV heart failure. Data adjusted for the impact of COVID-19 show a strong reduction in
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Until now, patients with heart failure with preserved ejection fraction – the most common type of heart failure in the elderly – have had no access to evidenced-based treatments. For the first time, a large clinical trial led by Prof. Dr. Stefan Anker from Charité – Universitätsmedizin Berlin has identified a drug which has a
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CINCINNATI, Aug. 26, 2021.  Airway Therapeutics, Inc. (Airway), a biopharmaceutical company developing a new class of biologics to break the cycle of injury and inflammation for patients with respiratory and inflammatory diseases, announced dosing of the first patient on August 17, 2021 in the AT-100 (rhSP-D) Phase 1b trial in mechanically-ventilated COVID-19 patients. The clinical
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NEW YORK, Aug. 24, 2021. Oramed Pharmaceuticals Inc., a clinical-stage pharmaceutical company focused on the development of oral drug delivery platforms, announced today that it has enrolled and randomized over 25% of the planned 450 patients for its Phase 3 ORA-D-013-2 trial of its oral insulin capsule ORMD-0801 for the treatment of type 2 diabetes
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The ongoing coronavirus disease 2019 (COVID-19) pandemic has severely impacted the world’s healthcare system and economy. COVID-19, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected over 214 million and claimed the lives of almost 4.5 million worldwide. Individuals can be protected from SARS-CoV-2 via immunity that is induced by
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Monday, August 23, 2021. Randomized, double-blind, placebo-controlled study did not meet the primary endpoint: change in the total Mayo score at week eight, relative to placebo Izencitinib was well-tolerated and safety data were consistent with expectations for this gut-selective pan-JAK inhibitor DUBLIN and SOUTH SAN FRANCISCO, Calif., /PRNewswire/ — Theravance Biopharma, Inc. (“Theravance Biopharma” or
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Monday, August 16, 2021 Phase 1 safety and immunogenicity data in individuals who received a third dose of the Pfizer-BioNTech vaccine (BNT162b2) show a favorable safety profile and robust immune responses The booster dose elicited significantly higher neutralizing antibody titers against the initial SARS-CoV-2 virus (wild type), and the Beta and Delta variants, compared to
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A stress signal received by the heart from fat could help protect against cardiac damage induced by obesity, a new study led by UT Southwestern researchers suggests. The finding, published online in Cell Metabolism, could help explain the “obesity paradox,” a phenomenon in which obese individuals have better short- and medium-term cardiovascular disease prognoses compared
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